Commonly used veterinary drugs - contraindications of cephalosporins

1. Commonly used varieties of
  first-generation cephalosporins: cephradine, cefazolin (for injection only), cephalexin, cephalothin, cefadroxil, etc.
  Second-generation cephalosporins: cefamandole, cefuroxime, cefotiam, etc.
  Third-generation cephalosporins: cefotaxime sodium, ceftazidime, cefoperazone sodium, ceftizoxime, ceftiofur, etc.
  Fourth-generation cephalosporins: cefquinoxime.
  2. Drug indications
  Cefalexin is used for the treatment of chicken Staphylococcus aureus and colibacillosis. Cefuroxime is used for the control of Salmonella and Escherichia coli. Ceftiofur in the treatment of Salmonella, colibacillosis and Pseudomonas aeruginosa in chickens. At the same time, it has a good effect on the prevention and treatment of Pasteurella anatipestifer. After ceftiofur sodium salt was mixed with Marek vaccine at 4°C for 20 hours, there was no change in plaque forming units (PFU) of the vaccine, and at the same time, the mortality rate of hatched chicks was significantly reduced.
  3. The effect of drug use (
  1) the effect of preventing and treating Staphylococcus aureus and streptococcus: cephradine, cefazolin, cephalothin, cephalexin > cefamando > cefuroxime > ceftazidime (2) prevention and treatment of Escherichia coli, salmonella, duck plague Effect of Pasteurella: ceftiofur, cefotaxime sodium > cephradine, cephalexin ⑶ effect of prevention and treatment of Pseudomonas aeruginosa: cefotaxime sodium, ceftiofur > cefamandol > cephalexin 4, drug dosage
  cephradine, For cephalexin, cephalothin, and ceftiofur, add 80-100g per 1000kg of feed, and use it continuously for 3-5 days. Poultry ceftiofur injection is 10-20 mg per kg body weight.
  5. Compatibility of drugs Combination of
  cephalosporins with gentamicin, kanamycin and neomycin can produce synergistic or additive effects. However, the main excretion route of ceftiofur is the kidney, so the nephrotoxicity is relatively strong, and it cannot be used in combination with other drugs with strong nephrotoxicity, such as aminoglycoside antibiotics such as amikacin and gentamicin. Animals with renal insufficiency should pay attention to adjusting the dosage appropriately.
  6. Incompatibility of drugs
  Combination of cephalosporins with erythromycin, leucomycin, chloramphenicol, etc. will lead to weakening of their antibacterial effect.
  7. The residual time of this type of drug is
  tentatively set at 5 days

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