Digestive Pharmacology of Florfenicol and Compatibility in Treatment of Gastrointestinal Diseases

Mention of florfenicol products can be seen almost everywhere in grass-roots veterinary drug stores, and it is also one of the commonly used drugs in major breeding companies. However, there is no doubt that everyone knows that florfenicol alone has the most prominent clinical therapeutic value: it is used for the treatment of respiratory diseases in livestock and poultry.
  As for other application values of florfenicol products in animal breeding production, few people have been exploring for so many years. This is a very regrettable thing, and it deserves the attention of front-line veterinarians in researching drug application and practice.
  The root cause of the difficult use of florfenicol products?
  What people get from professional drugs and pharmacology books is the theoretical drug and pharmacological knowledge of Florfenicol, but what the majority of grassroots veterinarians really need is: the pharmacological knowledge of the clinical application of Florfenicol, which is currently hindering The biggest obstacle to the correct use of Florfenicol products! At present, only human medicine has professional books in this area, but there is not a single professional book in this area in terms of animal medicine and pharmacological application research!
  Here we can take florfenicol as an example. The professional books on florfenicol that you have seen, as well as the contents of the "pharmacological action" section on the product label instructions of florfenicol, are all based on laboratory research and Analytical "models", "simulations" of "ex vivo" theoretical pharmacology. Rather than "clinical application pharmacology" combined with specific animal physiology, pathogens, pharmacokinetics and drug effects.
  Digestive pharmacology of Florfenicol
  1. Florfenicol has good antibacterial effect on Escherichia coli, Salmonella, Pasteurella and some anaerobic bacteria that cause gastrointestinal diseases; 2. Florfenicol is rapidly absorbed orally, 1 The effective therapeutic concentration can be reached within hours, and the bioavailability is over 80%; 3. For poultry with a relatively short digestive tract, there will be more florfenicol that is too late to be absorbed and stay in the digestive tract; 4. So Let's say, oral administration of florfenicol to chickens is also better for the treatment of chicken bacterial gastrointestinal diseases.
  However, the scientific application of florfenicol in the treatment of chicken digestive tract diseases does not mean that florfenicol alone will be effective. The reason is: Florfenicol is not sensitive to all pathogenic bacteria that cause digestive tract diseases in poultry! Especially for Escherichia coli with a relatively high drug resistance rate and some facultative anaerobic bacteria, it is necessary to synergize and strengthen the antibacterial effect!
  Then, the water-soluble florfenicol and colistin sulfate should be used in a synergistic ratio of 5:6, and at least 5 grams of florfenicol should be used according to the treatment amount of 100 kg of water, so as to treat more difficult-to-treat bacteria Enteritis is effective.
  This synergistic ratio between highly water-soluble florfenicol and colistin sulfate not only enhances the antibacterial effect on gastrointestinal diseases through multiple antibacterial effects, but also expands the antibacterial spectrum of the "prescription" against gastrointestinal pathogens , so as to ensure the therapeutic effect of the prescription for enteritis.
  ● Conversely, although the use of florfenicol products for poultry gastrointestinal diseases is suitable for poultry’s digestive tract physiology and florfenicol’s digestive tract pharmacology, but the antibacterial spectrum and action intensity of florfenicol itself ( Including drug resistance), florfenicol products alone are not effective in the treatment of poultry enteritis enterotoxicity.

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