What are the Possibilities for ADCs Targeting Trop2?
Antibody drug conjugate (ADC) research involves more and more targets, such as HER-2, Trop-2, Claudin-18.2, B7-H3 and B7-H4, etc. Trop-2 is a transmembrane glycoprotein. Its high expression is associated with the occurrence of many tumors and poor prognosis. It is a very popular ADC resear...
31 October 2023
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Krystal Beily
mRNA Strategies for Cancer Immunotherapy
Cancer immunotherapy holds enormous potential in combating malignant tumors. Messenger ribonucleic acid (mRNA) has emerged as a widely studied tool in recent years, functioning within the cytoplasm and eliminating the risk of unintentional insertion or mutation that was associated with plasmid DNA (...
31 October 2023
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Krystal Beily
Lipid Nanoparticles (LNPs) Design and Formulation Production
Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came to the fore during the COVID-19 pandemic, lipid nanoparticles (LNP) are undoubtedly the most advanced and w...
31 October 2023
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Krystal Beily
Large-scale RNA Production Through Fermentation
Why RNA production by fermentation
RNA is a vital biomolecule with numerous biological functions, and its importance has led to a growing demand for RNA-based therapeutics and diagnostic tools. However, producing RNA at a large scale has been a challenge, and traditional methods such as chemical sy...
31 October 2023
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Krystal Beily
Based on Antibody Targeted Protein Degradation
In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell's own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the most promising methods. Apart from PROTAC, various targeted protein degradation (TPD) strategies are emerging, invo...
31 October 2023
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Krystal Beily
Drug-to-Antibody Ratio Analysis Methods
Average drug-to-antibody ratio (DAR) and drug load distribution are two vital properties of antibody drug conjugates (ADCs). Over the years, several ADC bioanalytical methods have...
04 August 2023
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Krystal Beily
A Brief Guide to Pichia pastoris Fermentation
What is pichia pastoris and its functions?
Pichia pastoris is a type of yeast that is commonly used in biotechnology for the production of recombinant proteins. It is known for its ability to efficiently produce heterologous proteins with high yields. Pichia pastoris offers seve...
04 August 2023
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Krystal Beily
The Notable Breakthroughs in Drug Discovery with SILAC Technique
Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) is a powerful technique that allows for the quantification and characterization of proteins in cells and organisms. It involves the substitution of specific amino acids with their isotopically labeled counterparts in cell culture media....
04 August 2023
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Krystal Beily
How to Find the Right Partner for Custom Chemical Synthesis
What can CROs do in custom synthesis?
Process development and optimization: CROs can work with clients to develop and optimize synthetic routes for the production of target compounds. They can design and scale-up synthetic processes to efficiently produce desired molecules.
Medicinal chemistr...
04 August 2023
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Krystal Beily