How much do you know about the use of colistin sulfate?

In the daily drug use in aquaculture, we found that due to lack of technical knowledge, farmers caused blind and irrational drug use. So, today, let's get to know  Colistin sulfate, a commonly used drug for livestock and poultry.

Colistin sulfate is an alkaline polypeptide antibiotic, which is a biological drug obtained by microbial fermentation and contains a polyhydroxy structure in its molecular structure; later, through a semi-synthetic production process, the chemical property of "colistin sulfate" is obtained. Acidic compounds. Therefore, colistin is an alkaloid, and the clinical drug "colistin sulfate" is physicochemically acidic.

Prominent antibacterial effect of colistin sulfate

In the current pursuit of the efficacy of acidifiers in aquaculture, colistin sulfate not only has the characteristics of acidifiers: it creates an acidic environment in the digestive tract, which is not conducive to the growth and reproduction of harmful bacteria; it also promotes food intake and is green and free of drug residues.

In addition to the advantages of acidifiers, colistin sulfate also has advantages that acidifiers do not have at all. That is: low-concentration bacteriostatic, therapeutic dose sterilization, and outstanding effect; moreover, colistin sulfate can significantly improve the feed conversion rate and reduce the feed-to-meat ratio, thereby improving the efficiency of breeding.

Strong action against Gram-negative bacteria

Colistin sulfate mainly acts on the cell membrane of bacterial cells. It binds to the free phosphate of gram-negative bacterial cell membrane lipoprotein by adsorbing the bacterial cell wall, so that the cell components (purines and pyrimidines) escape, and the surface tension of the cell membrane is reduced. Small, increased permeability, leading to leakage of important substances in cells such as amino acids, purines, pyrimidines, K+, etc., resulting in bacterial death.

Therefore, the antibacterial spectrum of colistin sulfate is mainly against Gram-negative bacteria, and it has a strong effect on negative bacteria, especially against Escherichia coli, Salmonella, Pseudomonas aeruginosa, Proteus and Haemophilus. deactivation and inhibition. It has little effect on Gram-positive bacteria (except Staphylococcus aureus and Streptococcus hemolyticus) and fungi.

Into the body, the maintenance time is relatively short

Colistin sulfate has the best stability and the strongest activity in the pH range of pH 3-7.5. Its oral administration is difficult for the body to absorb; unless the digestive tract has inflammation, ulcers and other incomplete digestive tract mucosa, a small amount of colistin sulfate may be passively absorbed. However, the absorbed colistin sulfate is poorly distributed in animals. It is administered by injection, and colistin sulfate can only reach effective therapeutic concentrations in the lung, heart, liver and trachea.

After 8 hours of oral administration, except for bile, there are only trace residues in other tissues; after 16 hours of oral administration, all tissues have no residues. 6 hours after injection, other organs and tissues are difficult to detect except blood, trachea, salivary glands, kidneys, and urine; 24 hours after injection, other organs and tissues except trachea, kidneys, and urine are difficult to detect. It is also difficult to detect.

Currently in livestock and poultry veterinary clinics, it is only allowed to use drugs for the treatment of diseases.

When using colistin sulfate, different drug purposes and the compatibility of the combination drug are different, and its effective dosage and compatibility ratio are different. For example, the combined use of colistin sulfate and amoxicillin has different treatments for the respiratory system, digestive system, pericarditis and perihepatitis; as a combination drug for anti-drug resistance and synergistic use, Only when the proportion and dosage of synergistic effect are achieved, will the proper use effect be achieved.

https://www.arshinepharma.com/info/how-much-do-you-know-about-the-use-of-colistin-73773546.html